Cover Feature: In Vitro Selection and Characterization of a DNAzyme Probe for Diverse Pathogenic Strains of <i>Clostridium difficile</i> (Chem. Eur. J. 36/2023)

An RNA-cleavage fluorogenic DNAzyme has been made for recognizing diverse strains of Clostridium difficile that frequently cause an infectious disease known as C. infection (CDI). Upon encountering cells, this cuts itself to produce a fluorescent signal, thus making it useful molecular probe CDI diagnosis. This is highly specific stays silent in the presence several control bacterial cells. The intriguing secondary structure with pseudoknot arrangement essential its functionality. More information can be found Research Article by Y. Li and co-workers (DOI: 10.1002/chem.202300240).